Generalized pustular psoriasis of von Zumbusch. A case report




Lorenza M. Luengo-Fernández, Servicio de Dermatología, Hospital General de México Dr. Eduardo Liceaga, Ciudad de México, México
Uriel Pérez-García, Servicio de Dermatología, Hospital General de México, Ciudad de México, México
Andrés Tirado-Sánchez, Servicio de Dermatología, Hospital General de México Dr. Eduardo Liceaga, Ciudad de México, México
María I. Arellano-Mendoza, Dermatology Service, Hospital General de México “Dr. Eduardo Liceaga”, Mexico City. Mexico
Rosa M. Ponce-Olivera, Servicio de Dermato-Oncología y Cirugía Dermatológica, Hospital General de México Dr. Eduardo Liceaga. Ciudad de México, México
Patricia Mercadillo-Pérez, Servicio de Dermatopatología. Hospital General de México, Ciudad de México, México


Psoriasis is a chronic inflammatory disease with a prevalence of 1-3% worldwide. Generalized pustular psoriasis is the most severe clinical variant of psoriasis and represents only 1.8% of all psoriasis cases. Its etiology is uncertain, although it has been associated with the abrupt withdrawal of both systemic and/or topical corticosteroids. It is characterized by sterile pustules overlying painful erythematous skin and it may present with severe systemic involvement. We here present a case of generalized pustular psoriasis in a male with no severe systemic involvement, related to irregular and interrupted use of betamethasone cream, who responded favorably to methotrexate.



Keywords: Psoriasis. Generalized pustular psoriasis. von Zumbusch. Corticosteroids.